Xeljanz Tofacitinib Tablet

Description

Tofacitinib 5 mg can lower the ability of your immune system to fight infections. Do not start taking Tofacitinib if you have any kind of infection unless your healthcare provider tells you it is okay. Serious Infections have happened in people taking Tofacitinib. These serious infections include tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider should test you for TB before starting and during treatment with Tofacitinib.Before and after starting Tofacitinib, tell your doctor if you have an infection or symptoms of an infection, including:Fever, sweating, or chillsCoughBlood in phlegmWarm, red, or painful skin or sores on your bodyBurning when you urinateUrinating more often than normalMuscle achesShortness of breathWeight lossDiarrhea or stomach painFeeling very tiredIncreased risk of death in people 50 years of age and older with rheumatoid arthritis who have at least 1 heart disease (cardiovascular) risk factor and who are taking a higher than recommended dose of Tofacitinib/Tofacitinib XR. The recommended dose in patients with rheumatoid arthritis and psoriatic arthritis is Tofacitinib 5 mg twice daily or Tofacitinib XR 11 mg one time each day.Cancer. Tofacitinib may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers, including skin cancers, can happen. Tell your healthcare provider if you have ever had any type of cancer.Higher dose. People taking the higher dose of Tofacitinib (10 mg twice daily) or Tofacitinib XR (22 mg one time each day) have a higher risk of serious infections, shingles, or skin cancers.Immune System Problem. Some people who have taken Tofacitinib with certain other medicines to prevent kidney transplant rejection have had a problem with certain white blood cells growing out of control (Epstein Barr Virus–associated post-transplant lymphoproliferative disorder).Blood clots in the lungs (pulmonary embolism, PE), veins of the legs (deep vein thrombosis, DVT) and arteries (arterial thrombosis) have happened more often in patients with rheumatoid arthritis who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a higher than recommended dose of Tofacitinib/Tofacitinib XR. Blood clots in the lungs have also happened in patients with ulcerative colitis. Some people have died from these blood clots.• Stop taking Tofacitinib and tell your healthcare provider right away if you have any signs and symptoms of blood clots such as sudden shortness of breath, difficulty breathing, chest pain, swelling of a leg or arm, leg pain or tenderness, or red or discolored skin in the leg or arm.Tears (perforation) in the stomach or intestines. Tell your healthcare provider if you have had diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines. Some people taking Tofacitinib can get tears in their stomach or intestine. This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or methotrexate. Tell your healthcare provider right away if you have fever, stomach-area pain that does not go away, and a change in your bowel habits.Serious allergic reactions can occur. Stop using Tofacitinib and call your healthcare provider right away if you have swelling of your lips, tongue, throat, or get hives.