Olaparib Film Coated Tablets 150mg

Description

OLAPARIB is a prescription medicine used to treat adults who have:advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer with a certain type of inherited (germline) or acquired (somatic) abnormal BRCA gene. OLAPARIB is used alone as maintenance treatment after the cancer has responded to your first treatment with platinum-based chemotherapy. Your healthcare provider will perform a test to make sure that OLAPARIB is right for youovarian cancer, fallopian tube cancer, or primary peritoneal cancer, as maintenance treatment, when the cancer has come back. OLAPARIB is used after the cancer has responded to treatment with platinum-based chemotherapyadvanced ovarian cancer with a certain type of abnormal inherited BRCA gene, and have received treatment with 3 or more prior types of chemotherapy medicines. Your healthcare provider will perform a test to make sure that OLAPARIB is right for youa certain type of abnormal inherited BRCA gene, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body (metastatic). You should have received chemotherapy medicines, either before or after your cancer has spread. If you have hormone receptor (HR)-positive disease, you should have been treated with hormonal therapy. Your healthcare provider will perform a test to make sure that OLAPARIB is right for you.IMPORTANT SAFETY INFORMATION OLAPARIB may cause serious side effects, including:Bone marrow problems called Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). Some people who have ovarian cancer or breast cancer and who have received previous treatment with chemotherapy, radiotherapy, or certain other medicines for their cancer have developed MDS or AML during treatment with OLAPARIB. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with OLAPARIB.Symptoms of low blood cell counts are common during treatment with OLAPARIB, but can be a sign of serious bone marrow problems, including MDS or AML. Symptoms may include weakness, weight loss, fever, frequent infections, blood in urine or stool, shortness of breath, feeling very tired, bruising or bleeding more easily.Your healthcare provider will do blood tests to check your blood cell counts:before treatment with OLAPARIBevery month during treatment with OLAPARIBweekly if you have low blood cell counts that last a long time. Your healthcare provider may stop treatment with OLAPARIB until your blood cell counts improveLung problems (pneumonitis). Tell your healthcare provider if you have any new or worsening symptoms of lung problems, including shortness of breath, fever, cough, or wheezing. Your healthcare provider may do a chest x-ray if you have any of these symptoms. Your healthcare provider may temporarily or completely stop treatment if you develop pneumonitis. Pneumonitis may lead to death.Before taking OLAPARIB, tell your healthcare provider about all of your medical conditions, including if you:have lung or breathing problemshave kidney problemsare pregnant, become pregnant, or plan to become pregnant. OLAPARIB can harm your unborn baby and may cause loss of pregnancy (miscarriage)If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with OLAPARIBFemales who are able to become pregnant should use effective birth control (contraception) during treatment with OLAPARIB and for 6 months after the last dose of OLAPARIB. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you might be pregnant following treatment with OLAPARIBMales with female partners who are pregnant or able to become pregnant should use effective birth control (contraception) during treatment with OLAPARIB and for 3 months after the last dose of OLAPARIB